Physiology and Metabolism of Thyroid

Thyroid Physiology

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Thyroid Physiology

Thyroid hormones i.e., activities of T4 and T3 are produced by the follicular cells of the thyroid gland and are regulated by TRH & TSH synthesis made by the thyrotropes of the anterior pituitary gland. The effects of T4 in vivo are mediated via T3 (T4 is converted to T3 in target tissues).Proteases digest iodinated thyroglobulin by Thyroglobulin synthesis, releasing the hormones T4 and T3. The biologically active agents for mechanism of transcriptional regulation, leading to increase the production and plays a major role of thyroid-stimulating hormone, which causes the thyroid to enlarge for the regulation of Thyroid hormone receptors gene expression by binding to hormone response elements (HREs) in DNA either as monomers, heterodimers with retinoid X receptor. Thyroid hormones will also effects on Nutrient Sources and also effects on organ systems. 

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